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Updated: Jun 12, 2026

23:06
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
多剤耐性および広範囲耐性結核:結核の世界的な制御に対する脅威
Neel R Gandhi1, Paul Nunn, Keertan Dheda
1Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10467, USA. neelgandhi@alumni.williams.edu
Lancet (London, England)
|May 22, 2010
まとめ
多剤耐性結核 (MDR TB) は,世界的に特定され,治療されている症例はほとんどなく,増大する脅威です. この世界的な健康問題と闘うには,診断,治療,国家政策の緊急改善が不可欠です.
科学分野:
- 公衆衛生は公衆衛生である.
- 感染症 感染症は感染症です.
- グローバル・ヘルス・セキュリティー グローバル・ヘルス・セキュリティー
背景:
- 薬剤耐性結核の減少に向けた世界的な進展は,多剤耐性 (MDR) と広範囲耐性 (XDR) 結核の増加によって脅かされている.
- 現在の対応率は不十分であり,世界的にMDR結核症例が特定され,治療されている割合は低い.
研究 の 目的:
- MDRおよびXDR結核の増大する脅威に対する各国による遅い対応を強調する.
- 研究室の容量,感染制御,治療プログラムの改善の必要性を強調する.
- 薬剤耐性結核との闘いにおける国家政策と保健システムの改善の重要性を強調する.
主な方法:
- 世界的な結核の発生率と治療データの分析.
- MDRおよびXDR結核の既存の診断技術と薬物のレビュー.
- MDR結核の制御のための成功した国レベルの戦略の検討.
主要な成果:
- 2008年に推定されたMDR結核の症例の7%のみが特定され,WHOに報告され,適切な治療を受けたのは5分の1のみでした.
- MDRおよびXDR結核の治療は,薬剤感受性結核の治療よりもはるかに費用がかかり,成功率も低い.
- いくつかの国は,既存の技術が10年以内にMDR結核の流行を逆転させることができることを実証しています.
結論:
- MDRおよびXDR結核の診断と治療の大規模な拡大は,薬剤耐性菌株が支配的になるのを防ぐために非常に重要です.
- 実験室の容量,感染症対策,結核対策プログラムの大幅な改善が必要である.
- 国家政策へのコミットメント,保健システムの強化,治療への財政的アクセシビリティは,特に高負担国において不可欠です.
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