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Updated: Jun 12, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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オキシラン形成のソープ・インゴールド加速は,主に溶媒効果によるものです

Jakub Kostal1, William L Jorgensen

  • 1Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, USA.

Journal of the American Chemical Society
|June 8, 2010
PubMed
まとめ

ソープ・インゴールド仮説は,サイクライゼーション反応におけるジェム・ディメチル効果を説明する. 計算による研究では,固有の反応性ではなく,溶媒効果が,アルファメチル化によって観測された速度増加を誘導することを示しています.

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