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Nuclear Power
Controlled nuclear fission reactions are used to generate electricity. Any nuclear reactor that produces power via the fission of uranium or plutonium by bombardment with neutrons has six components: nuclear fuel consisting of fissionable material, a nuclear moderator, a neutron source, control rods, reactor coolant, and a shield and containment system.
Nuclear Fuels
Nuclear fuel consists of a fissile isotope, such as uranium-235, which must be present in sufficient quantity to provide a...
Nuclear Fuels
Nuclear fuel consists of a fissile isotope, such as uranium-235, which must be present in sufficient quantity to provide a...
Nuclear Fusion
The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
Nuclear Transmutation
Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed protons being...
Introduction to Nuclear Reprogramming
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
Somatic to iPS Cell Reprogramming
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Methods of Nuclear Reprogramming
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
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3つのアプローチによる多能状態への核再プログラミング
Shinya Yamanaka1, Helen M Blau
1Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan.
Nature
|June 11, 2010
まとめ
成人細胞は,異なる細胞タイプに再プログラムされ,重要な細胞の可塑性を示します. この再プログラミングは,様々な方法によって達成され,将来の医療アプリケーションの有望さを秘めています.
科学分野:
- 細胞および分子生物学
- 発達生物学 発達生物学について
- 再生医学は,再生医療である.
背景:
- 分化細胞の安定状態は,動的に制御され,乱れに敏感です.
- 細胞の再プログラミングにより,成体細胞は遺伝子発現と細胞運命を変化させることができます.
研究 の 目的:
- 細胞の再プログラミングのメカニズムと影響を調査する.
- 誘導された細胞の可塑性の潜在的な医学的な応用を強調する.
主な方法:
- 核の移転について
- 細胞融合は細胞融合である.
- トランスクリプション・ファクター・トランスデュークション
主要な成果:
- "末端分化"した体細胞核が再プログラム可能であることを示した.
- 再プログラムされた体細胞における胚性幹細胞遺伝子の誘発発現を示した.
- 再プログラムされた細胞が様々な細胞タイプに分化する可能性を確認した.
結論:
- 細胞の可塑性は,分化細胞の重要な特徴であり,再プログラミングを可能にします.


