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Updated: Jun 12, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
04:38

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions

Published on: July 28, 2022

N-プロトン化アミドの構造的特徴: 中間ブリッジのねじれたラクトームの地域選択的なN活性化

Michal Szostak1, Lei Yao, Victor W Day

  • 1Department of Medicinal Chemistry, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, Kansas 66047, USA.

Journal of the American Chemical Society
|June 12, 2010
PubMed
まとめ

酸でラクトームをプロトネーションすると,N-プロトネーションされたラクトームが生み出され,アミド結合の非平面性が大幅に増加します. この構造的歪みは,化学反応におけるアミド結合の活性化に不可欠である.

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