関連する実験動画
血清のビタミンB濃度と肺がんのリスク
Mattias Johansson1, Caroline Relton, Per Magne Ueland
1International Agency for Research on Cancer, Lyon, France.
JAMA
|June 17, 2010
まとめ
ビタミンB6とメチオニンの血清濃度の上昇は,肺がんのリスク低下と関連しています. これらの発見は,これらの1炭素代謝因子の肺がん予防における潜在的な役割を示唆しています.
科学分野:
- 栄養学的生化学について
- 癌の流行病学 がん流行病学
- 分子生物学は分子生物学である.
背景:
- ビタミンBと1炭素代謝因子は,DNAの完全性と遺伝子発現に不可欠です.
- これらの要因は,肺がんを含むがんのリスクに影響を与える可能性があります.
研究 の 目的:
- 1炭素代謝因子と肺がんの発生率との関連を調べる.
- 肺がんの発症における特定のビタミンBおよび関連する代謝物の役割を調査する.
主な方法:
- 癌と栄養に関する欧州展望調査 (EPIC) のコホート (n=385,747) のデータを活用した.
- ビタミンB6,葉酸,ビタミンB12,メチオニン,ホモシステインの血清濃度が測定されました.
- 899例の肺がんと1770例の対照群をマッチングし,代謝産物のレベルに基づいて肺がんリスクの確率比を分析した.
主要な成果:
- ビタミンB6の血清濃度の上昇は,肺がんリスクの有意な低下と関連していた (OR,0.44).
- 血清メチオニンの上昇は,肺がんリスクと強い逆関連性も示した (OR,0.52).
- ビタミンB6とメチオニンの高濃度の組み合わせにより,肺がんのリスクがさらに低下しました (OR,0.41).
結論:
- 血清のビタミンB6とメチオニンのレベルは,肺がんのリスクと逆に関連しています.
- これらの発見は,十分なビタミンBとメチオニンの状態が肺がんに対する潜在的な保護的役割を強調しています.
関連する概念動画
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Serum Studies: Renal Function Tests
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Vitamins
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Serum Laboratory Studies, Stool Test, Breath Test
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...