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Updated: Jun 12, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

ダイアステロセレクティブスピロサイクリングによる完全に置換された炭素センター: (+) -レパディホルミンCのステレオセレクティブ合成

Matthew A Perry1, Matthew D Morin, Brian W Slafer

  • 1Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, USA.

Journal of the American Chemical Society
|June 29, 2010
PubMed
まとめ

N-Bocアルファ-アミノニトリルの還元性リチウム化により,驚くべき選択性を持つアルファ-アミノアルキルリチウム反応剤が得られます. このステレオ選択的方法は,複雑なスパイロ化合物や,レパディホルミンCのような自然産物の合成を可能にします.

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