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Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

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Updated: Jun 11, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
04:36

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

糖尿病性網膜病変症 糖尿病性網膜病変症 糖尿病性網膜病変症 糖尿病性網膜病変症とは

Ning Cheung1, Paul Mitchell, Tien Yin Wong

  • 1Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.

Lancet (London, England)
|June 29, 2010
PubMed
まとめ
この要約は機械生成です。

糖尿病の合併症である糖尿病性網膜症は,予防可能な失明を引き起こす. 血糖,血圧,脂質の管理は,レーザー療法などの適切な治療とともに,視力を保ち,視力喪失を防ぐための鍵です.

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Retinal Pathophysiological Evaluation in a Rat Model
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Retinal Pathophysiological Evaluation in a Rat Model

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Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tg(fli:EGFP) Zebrafish Retinal Vasculature
10:07

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tg(fli:EGFP) Zebrafish Retinal Vasculature

Published on: December 26, 2017

関連する実験動画

Last Updated: Jun 11, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
04:36

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

Retinal Pathophysiological Evaluation in a Rat Model
09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tg(fli:EGFP) Zebrafish Retinal Vasculature
10:07

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tg(fli:EGFP) Zebrafish Retinal Vasculature

Published on: December 26, 2017

科学分野:

  • オフタルモロジック (眼科)
  • エンドクリノロジー エンドクリノロジー
  • 血管医学 血管医学とは

背景:

  • 糖尿病性網膜症は,働く年齢の成人の予防可能な失明の主な原因です.
  • 糖尿病患者の3分の1に感染し,全身血管合併症のリスクを高めます.
  • 糖尿病性網膜症は,糖尿病の微血管合併症である.

研究 の 目的:

  • 糖尿病性網膜症の現在の理解と管理を要約する.
  • 網膜病変の予防におけるシステミック・リスクファクター・コントロールの重要性を強調する.
  • 糖尿病性網膜症の既定および新興の治療方法を検討する.

主な方法:

  • 糖尿病性網膜症に関する現在の文献のレビュー.
  • 血糖値,血圧,脂質コントロールの役割を分析する.
  • 従来の治療法と新しい治療法の評価.

主要な成果:

  • 血糖,血圧,脂質の最適なコントロールは,網膜症のリスクと進行を減らすために不可欠です.
  • レーザー療法は,増殖性網膜病変およびマキュラ腫では視力を保ちますが,視力喪失を逆転させる能力は限られています.
  • ステロイドの眼内注射や抗VEGF剤などの新しい治療法は,より破壊的な網膜治療の選択肢を提供しています.

結論:

  • 従来の治療法が存在しますが,糖尿病性網膜症の管理のために新しい治療法が生み出されています.
  • 再生性および局所療法を含む将来の治療法は,改善された結果の有望を示しています.
  • 効果的な管理には,リスク因子制御と適切な治療介入を含む多面的なアプローチが必要です.