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Updated: Jun 11, 2026

Purification of the Cystic Fibrosis Transmembrane Conductance Regulator Protein Expressed in Saccharomyces cerevisiae
15:12

Purification of the Cystic Fibrosis Transmembrane Conductance Regulator Protein Expressed in Saccharomyces cerevisiae

Published on: May 10, 2014

周辺タンパク質の品質管理は,プラズマ膜から展開されたCFTRを除去します

Tsukasa Okiyoneda1, Hervé Barrière, Miklós Bagdány

  • 1Department of Physiology, and Groupe de Recherche Axé sur la Structure des Protéine (GRASP) McGill University, Montreal, Quebec H3G 1Y6, Canada.

Science (New York, N.Y.)
|July 3, 2010
PubMed
まとめ

研究者らは,細胞表面で展開された性線維症トランスメブラン伝導性調節器 (CFTR) を退化させる周辺タンパク質品質管理システムを特定しました. このプロセスは,ユビキチネーションを含み,リゾソーム分解のために誤ったCFTRを標的とし,システィック線維症の治療戦略に影響を与えます.

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Expression and Purification of the Cystic Fibrosis Transmembrane Conductance Regulator Protein in Saccharomyces cerevisiae14:56

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