関連する実験動画

Updated: Jun 11, 2026

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
11:52

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level

Published on: April 23, 2016

LINE-1 人間のゲノムにおけるレトロトランスポーゼーション活性

Christine R Beck1, Pamela Collier, Catriona Macfarlane

  • 1Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA. cregina@umich.edu <cregina@umich.edu>

Cell
|July 7, 2010
PubMed
まとめ

高活性な長い間隔の元素-1 (LINE-1またはL1) 配列は,これまで考えられていたよりも,ヒト集団でより一般的です. 進行中のL1逆転移は,個体間の遺伝的多様性に大きく寄与する.

さらに関連する動画

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level11:04

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

Published on: May 19, 2019

Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR10:54

Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR

Published on: July 27, 2019

関連する概念動画

Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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LTR Retrotransposons03:08

LTR Retrotransposons

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Overview of Transposition and Recombination

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DNA-only Transposons

DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...