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Updated: Jun 11, 2026

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions
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NMRリラクゼーションによるアミロイドβモノマーとオリゴマーの交換のシナティクス

Nicolas L Fawzi1, Jinfa Ying, Dennis A Torchia

  • 1Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, USA.

Journal of the American Chemical Society
|July 8, 2010
PubMed
まとめ

研究者らは,アルツハイマー病におけるアミロイドβ (Abeta) ペプチドオリゴメリゼーションの運動学を研究した. NMRを用いて,単体アベタが約3秒の速度で検出不能のオリゴーマーに変換することを発見した.

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