関連する実験動画
2型糖尿病を予防するためのローシグリタゾンとメトホルミンの低用量併用療法 (CANOE試験):ダブルブラインドランダム化対照試験
Bernard Zinman1, Stewart B Harris, Jan Neuman
1Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada. zinman@lunenfeld.ca
Lancet (London, England)
|July 8, 2010
まとめ
低用量のロシグリタゾンとメトホルミンは,グルコース耐性が低下した患者の2型糖尿病の発症を著しく減少させた. この組み合わせ治療は,管理可能な副作用とともに,糖尿病の予防に有効であることが示されました.
科学分野:
- エンドクリノロジー エンドクリノロジー
- メタボリック疾患
- クリニック・トライアル 臨床試験
背景:
- 2型糖尿病の流行は,効果的な予防戦略を必要とします.
- CANOE試験では,糖尿病予防のための低用量併用療法が評価されました.
研究 の 目的:
- 低用量のロシグリタゾンとメトホルミンの併用療法の2型糖尿病の予防における有効性を調査する.
- グルコース耐性障害の患者におけるこの治療法の安全性と有効性を評価する.
主な方法:
- ダブルブラインド,ランダム化制御試験で,グルコース耐性が低下した207人の患者を対象とした.
- 参加者は,ロシグリタゾン (2 mg) とメトホルミン (500 mg) を1日2回,またはプラセボを平均3.9年間投与された.
- 主要アウトカム:経口グルコース耐性テストまたは断食プラズマグルコースによる糖尿病発症までの時間.
主要な成果:
- プラセボ (39%) と比較すると,アクティブ治療群で糖尿病を発症した参加者はかなり少なく (14%) でした.
- 糖尿病発症の相対リスクは66%,絶対リスクは26%減少した.
- 治療群の80%が正常なグルコース耐性を回復し,プラセボ群の53%が回復した. 治療群では下痢の増加が観察されました.
結論:
- 低用量のロシグリタゾンとメトホルミンの併用療法は,グルコース耐性障害のある人の2型糖尿病の予防に非常に効果的です.
- 組み合わせ治療は,主要な有害事象に関して,好ましい安全性プロファイルを示した.
- このアプローチは,糖尿病予防のための実行可能な戦略を提供します.
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