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Updated: May 5, 2026

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抗糖尿病薬は,Cdk5によって肥満に関連したPPARgammaのリン酸化を阻害する

Jang Hyun Choi1, Alexander S Banks, Jennifer L Estall

  • 1Department of Cancer Biology and Division of Metabolism and Chronic Disease, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

Nature
|July 24, 2010
PubMed
まとめ

高脂肪食はCdk5を活性化し,脂肪組織内のPPARgammaをリン酸化する. これは遺伝子発現を妨害し,アディポネクチンを減少させ,インスリン抵抗性につながる. このリン酸化を阻害することで,新しい抗糖尿病治療法を提供することができる.

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