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Updated: May 11, 2026

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
07:55

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP

Published on: October 17, 2015

SIRT1は,アルファ-セクレターゼ遺伝子ADAM10を活性化することでβ-アミロイドの産生を抑制する

Gizem Donmez1, Diana Wang, Dena E Cohen

  • 1Paul F. Glenn Laboratory and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Cell
|July 27, 2010
PubMed
まとめ

脳内のSIRT1の過剰発現は,アルツハイマー病 (AD) モデルにおけるβ-アミロイドプラークを減少させる. SIRT1の活性化は,ADやその他の神経変性疾患の治療のための潜在的な戦略です.

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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

Published on: January 25, 2018

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase11:57

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase

Published on: June 24, 2025

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