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妊娠中の高血圧と後の心血管リスク:共通の前例?
Pål R Romundstad1, Elisabeth B Magnussen, George Davey Smith
1Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway. paalr@ntnu.no
Circulation
|July 28, 2010
まとめ
妊娠前出血症と妊娠期高血圧は,将来の心血管疾患と関連しています. しかし,妊娠前の共同リスク要因が,妊娠状態そのものではなく,この関連性を大きく説明します.
科学分野:
- 心血管疾患の疫学について
- 生殖器の健康については,
- 公衆衛生は公衆衛生である.
背景:
- 妊娠前出血症と妊娠性高血圧は,長期的な心血管疾患 (CVD) のリスクを高めます.
- この関連性の根本的な原因については,さらなる調査が必要である.
研究 の 目的:
- 妊娠による高血圧が後のCVDリスクに寄与するかどうかを判断する.
- 妊娠中の因子の役割と,妊娠前の共同リスク因子の役割を区別する.
主な方法:
- ノルド・トレンデラグの健康調査 (HUNT) とノルウェーの医療出生登録簿からの縦断データを使用した.
- シングルトン出産の女性3225人を含め,妊娠前と妊娠後の血圧,BMI,血清脂質の測定を分析した.
主要な成果:
- 妊娠前不妊症/妊娠中高血圧の女性は,妊娠前のBMI,血圧,および不利な脂質プロフィールが高かった.
- 妊娠前の要因を調整すると,BMI (>65%) と血圧 (~50%) の観察された差異が有意に軽減されました.
- リピッドの差 (HDLコレステロールとトリグリセリド) も,調整後に大幅に減少した (それぞれ40%と72%).
結論:
- 妊娠中の高血圧疾患と妊娠後の心血管疾患のリスク因子の関連性は,主に妊娠前の共通のリスク因子に起因する.
- 妊娠中の高血圧障害は,長期的な心血管疾患のリスクを直接引き起こさない場合があります.
- 妊娠前の危険因子管理に重点を置くことは,将来のCVDを緩和するために非常に重要です.
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