心臓のポジトロン放出トモグラフィー/コンピュータトモグラフィー画像は,解剖学的および機能的に重要な冠動脈疾患を正確に検出します
S Kajander1, E Joutsiniemi, M Saraste
1Turku PET Centre, Turku, Finland.
Circulation
|July 28, 2010
まとめ
ハイブリッドポジトロン放出トモグラフィー (PET) /CTは冠動脈疾患を正確に検出します. この非侵襲的画像法では,CT血管図と perfusion 画像を組み合わせて,低線量放射線で診断の正確性を向上させています.
科学分野:
- 心臓病学 心臓病学
- 放射線学 放射線学
- 核医学は,核医学である.
背景:
- コンピュータートモグラフィー (CT) は冠動脈疾患 (CAD) の検出に広く使用されていますが,狭窄症の評価は不確実です.
- 輸血画像は,イシュケミアを特定し,治療をガイドするために不可欠です.
- ハイブリッド・ポジトロン・エミッション・トモグラフィー (PET) /CTは,効率的で定量的で低用量なプロトコルで,結合アンジオグラフィーと perfusion imaging を提供しています.
研究 の 目的:
- 冠動脈疾患の非侵襲的検出のための心臓ハイブリッドPET/CTの精度を評価する.
- ハイブリッドPET/CTの診断性能をCTアンジオグラフィとCTアンジオグラフィとパーフュージョンイメージング単独で,侵入性アンジオグラフィと比較するために.
主な方法:
- 中間的な前テスト確率のCADを有する107人の患者は,ハイブリッドのPET/CTを用いた定量的なPET/(15) O-水とCT血管撮影を受けた.
- 結果は,適用可能な場合,分量フローリザーブ測定を含む侵襲性血管撮影に対して検証されました.
- 潜在的なトリガーおよびスパイラルCTプロトコルのための放射線用量が記録されました.
主要な成果:
- ハイブリッドPET/CTは冠動脈疾患の検出において98%の精度を達成し,単独のCT血管図 (81% PPV) と単独の perfusion imaging を大幅に上回った.
- PET/CTとCTアニオグラフィの両方が97%のネガティブな予測値を示しました.
- 放射線量は低いもので,潜在的なトリガープロトコルでは平均9.3mSvであった.
結論:
- 心臓ハイブリッドPET/CTは,症状のある個人に冠動脈疾患の正確な非侵襲的診断を提供します.
- このイメージング方式は,日常的な臨床使用で実現可能である.
- ほとんどの患者は10mSv未満の放射線被曝で処置を受けることができます.
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