脊椎動物の第2ハートフィールドの初期のコード系起源
Alberto Stolfi1, T Blair Gainous, John J Young
1Center for Integrative Genomics, Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Science (New York, N.Y.)
|July 31, 2010
まとめ
この研究では,単純な状心臓の原始細胞が心房シフォン筋肉の前駆体を形成し,脊椎動物の第2心臓フィールド (SHF) の原始細胞と遺伝子発現を共有することを明らかにしました. これは,心筋の共通の進化的起源を示唆している.
科学分野:
- 発達生物学 発達生物学とは
- 進化的発達生物学 進化的発達生物学
- コルダート胚学
背景:
- 脊椎動物の心臓は,第1および第2の心臓フィールド (SHF) を含む,異なる胚の領域から発達します.
- SHFは右心室と流出管の形成に不可欠ですが,その進化の歴史はほとんど知られていません.
研究 の 目的:
- 第2心場 (SHF) の進化的起源を調査する.
- 脊椎動物の心臓の進化に光を当てることができる,より単純な状動物における同質的な発達経路を特定する.
主な方法:
- 単純な状動物シオナ・インテスティナリスを用いた比較胚学.
- 心臓の祖先細胞における遺伝子発現パターンの分析.
- COEなどの転写因子の役割を調査する.
主要な成果:
- Ciona intestinalisの心臓前駆細胞は,心房シフォン筋 (ASM) の前駆体を生成する.
- これらの前駆体は,脊椎動物のスプランク性メソデルマやSHFに似た遺伝子発現 (Islet, Tbx1/10) を表している.
- 転写因子COEは,ASMの運命の重要な調節因子として特定されています.
結論:
- 多能な心筋の前駆体が,衣類類と脊椎動物の最後の共通の祖先に存在していたことを示唆している.
- これらの前駆体の再配分が脊椎動物のSHF.の進化に役立った可能性があることを示唆しています.
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