関連する実験動画

Updated: May 11, 2026

Assaying the Kinase Activity of LRRK2 in vitro
06:09

Assaying the Kinase Activity of LRRK2 in vitro

Published on: January 18, 2012

病原性LRRK2は,マイクロRNA媒介による翻訳抑制を否定的に調節する

Stephan Gehrke1, Yuzuru Imai, Nicholas Sokol

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA. sgehrke@stanford.edu

Nature
|July 31, 2010
PubMed
まとめ

レウシンに富んだリピートキナーゼ2 (LRRK2) の機能獲得変異は,マイクロRNA (miRNA) 経路を損なうことでパーキンソン病を引き起こす. これは,E2F1/DPの過剰生産につながり,神経変性を引き起こし,miRNAベースの治療法を提案します.

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Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag08:55

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