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Updated: Jun 10, 2026

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
07:33

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Published on: October 15, 2018

接触状態とタンパク質複合体の特定の形態の間の均衡を,インターフェース点変異によってシフトさせる

Alexander N Volkov1, Qamar Bashir, Jonathan A R Worrall

  • 1Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.

Journal of the American Chemical Society
|August 3, 2010
PubMed
まとめ

タンパク質複合体の形成には,一時的な遭遇状態が伴う. 研究者は,単一の突然変異が,タンパク質の相互作用における結合特異性と安定性を調整して,この状態を大幅に変化させることができることを発見しました.

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