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Updated: May 16, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

p53によって誘発された大規模なインタージェニック・ノンコーディングRNAは,p53応答におけるグローバルな遺伝子抑制を媒介する

Maite Huarte1, Mitchell Guttman, David Feldser

  • 1The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. mhuarte@broadinstitute.org

Cell
|August 3, 2010
PubMed
まとめ

研究者らは,p53.3によって調節される大型インター遺伝子非コーディングRNA (lincRNAs) を特定した. 1つのlincRNA,lincRNA-p21は抑制剤として作用し,hnRNP-Kと相互作用して遺伝子発現とアポトーシスを制御します.

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