Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Protein Organization01:13

Protein Organization

Overview
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Computational design of orthogonal TCR α/β interfaces for dual-TCR therapeutics.

bioRxiv : the preprint server for biology·2026
Same author

RNA secondary structure packages evaluated and improved by high-throughput experiments.

Nature methods·2022
Same author

Stabilizing proteins, simplified: A Rosetta-based webtool for predicting favorable mutations.

Protein science : a publication of the Protein Society·2022
Same author

PyRosetta Jupyter Notebooks Teach Biomolecular Structure Prediction and Design.

Biophysicist (Rockville, Md.)·2022
Same author

Comparative Analysis of Sulfonium-π, Ammonium-π, and Sulfur-π Interactions and Relevance to SAM-Dependent Methyltransferases.

Journal of the American Chemical Society·2022
Same author

Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks.

Nature communications·2021
Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026
Same journal

Towards the construction of a virtual yeast.

Nature·2026
Same journal

Aerosols and hydrocarbons in the atmosphere of a white dwarf planet.

Nature·2026
Same journal

TROP2 targeting reveals therapy-driven cell state dynamics in colorectal cancer.

Nature·2026
Same journal

Competing programs shape cortical sensorimotor-association axis development.

Nature·2026
Same journal

Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC.

Nature·2026
関連記事をすべて見る

関連する実験動画

Updated: May 12, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

マルチプレイヤーオンラインゲームでタンパク質の構造を予測する.

Seth Cooper1, Firas Khatib, Adrien Treuille

  • 1Department of Computer Science and Engineering, University of Washington, Box 352350, Seattle, Washington 98195, USA.

Nature
|August 6, 2010
PubMed
まとめ
この要約は機械生成です。

オンラインゲームは,複雑な科学的問題を解くことができます. タンパク質構造の予測ゲームであるFolditは,人間の問題解決と戦略開発を使用して,従来の方法が苦戦する解決策を見つけます.

さらに関連する動画

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

関連する実験動画

Last Updated: May 12, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

科学分野:

  • 計算生物学とは,計算生物学である.
  • バイオフィジックス 生物物理学
  • 構造生物学 構造生物学とは

背景:

  • ゲームを通じて科学的な問題をクラウドソーシングすることで,単純なタスクに成功した.
  • タンパク質構造の予測のような複雑な科学的課題は,依然として計算が密集しています.
  • タンパク質の原生構造を特定することは,広大な検索スペースがあるため困難です.

研究 の 目的:

  • 非科学者がタンパク質構造予測問題を解くためのマルチプレイヤーオンラインゲーム"Foldit"を紹介します.
  • ゲームによるヒューマン・ディレクテッド・コンピューティングが,複雑な科学的課題に対処できるかどうかを調査する.
  • 人間の問題解決をコンピューティングアルゴリズムと統合する可能性を探求する.

主な方法:

  • タンパク質構造予測のためのロゼッタアルゴリズムを利用したマルチプレイヤーオンラインゲーム"Foldit"を開発した.
  • 非科学者が直接操作ツールを使用してタンパク質構造と相互作用するよう促した.
  • プレーヤーは競争し,タンパク質エネルギー計算を最適化するために協力することができます.

主要な成果:

  • トップのFolditプレーヤーは,難しいタンパク質構造の精製問題を解く能力を示しました.
  • 協力的なゲームプレイは,プレイヤーによる新しい戦略とアルゴリズムの開発につながりました.
  • プレイヤーは,構成的および検索戦略の空間の両方を探求し,純粋に計算的アプローチを上回った.

結論:

  • インタラクティブなマルチプレイヤーゲームは,人間の視覚的な問題解決をコンピューティングアルゴリズムと効果的に統合することができます.
  • Folditは,コンピューティングに制限された科学的問題に取り組むための強力な新しいアプローチを表しています.
  • ゲーミングによるヒューマン・ディレクテッド・コンピューティングは,科学的発見を進めるための実行可能な戦略を提供します.