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妊娠体重増加と出生体重との関連:家族内の比較
1Department of Medicine, Children's Hospital, Boston, MA 02115, USA. david.ludwig@childrens.harvard.edu
Lancet (London, England)
|August 10, 2010
まとめ
妊娠中の過度の母親の体重増加は,遺伝学とは無関係に,より高い出生体重と関連しています. これは,妊娠中の体重管理が,小児肥満の予防に役立つ可能性があることを示唆しています.
科学分野:
- 産婦人科と産婦人科を担当しています.
- 小児科は小児科です.
- 公衆衛生は公衆衛生である.
背景:
- 妊娠中の過剰な体重増加は,子孫の出生体重の増加と,後の肥満のリスクと関連しています.
- 遺伝的および共通の環境要因は,観察された関連を混乱させる可能性があります.
- 兄弟のデータを用いた主題内デザインは,混同を軽減するのに役立ちます.
研究 の 目的:
- 母親の体重増加と子孫の出生体重との関連を調査する.
- この関連が遺伝的要因から独立しているかどうかを判断する.
- 妊婦を対象とした肥満予防戦略の情報提供.
主な方法:
- ミシガン州とニュージャージー州 (1989年-2003年) の出生登録データを用いた人口ベースのコホート研究.
- 妊娠期前または妊娠後の妊娠,母体糖尿病,極端な出生体重を除いて,複数のシングルトン出産をした女性を含みます.
- 妊娠中の体重増加が異なる同一の母親からの子孫の出生体重を比較するために,対象内のデザインを使用しました.
主要な成果:
- 分析には,513501人の女性から110万件以上の出産が含まれていました.
- 母親の体重増加と出生体重 (β = 7.35,p<0.0001) の間に有意な関連性が見つかりました.
- >24kgの体重が増えた女性は,148.9gの重さの赤ちゃんを産み,出生体重>4000gの確率は,8-10kgの体重増えた女性と比較して2.26倍でした.
結論:
- 妊娠中の母親の体重増加は,独立して子孫の出生体重を増加させます.
- 研究結果は,妊娠中の体重増加を管理するための介入が,小児肥満の予防に決定的な役割を果たす可能性があることを示唆しています.
- 妊娠中に健康的な体重増加に焦点を当てた公衆衛生の取り組みは正当化されています.
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