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Updated: Jun 10, 2026

The use of SC1 (Pluripotin) to Support mESC Self-renewal in the Absence of LIF
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Published on: November 18, 2009

Plzfは,mTORC1に対抗することによって,生殖線祖先の自己更新を調節する

Robin M Hobbs1, Marco Seandel, Ilaria Falciatori

  • 1Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Cell
|August 10, 2010
PubMed
まとめ

過度に活発なmTORC1シグナリングは,ニッチ信号を妨害することによって幹細胞を枯渇させます. 転写因子Plzfは,精子原始細胞の再生に不可欠なmTORC1を阻害することによって,幹細胞プールを維持する.

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