出産時の体重は,心房細動の発症の重要な危険因子です
David Conen1, Usha B Tedrow, Nancy R Cook
1Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass., USA. conend@uhbs.ch
Circulation
|August 11, 2010
まとめ
高い出生体重は,女性における心房細動 (AF) の発症リスクの増加と関連しています. これは,早期の生活要因がAFの発達に影響を及ぼす可能性があることを示唆しています.
科学分野:
- 心臓病学 心臓病学
- エピデミオロジー エピデミオロジー
- 生殖器保健は,生殖器の健康についてです.
背景:
- 出生体重と心房細動 (AF) の発生率の関係については,十分に研究されていない.
- 心房細動は,公衆衛生に重大な影響を及ぼす一般的な心不律です.
研究 の 目的:
- 出産時の体重と,女性における心房細動を発症するリスクとの関連を調査する.
- 心房細動の潜在的早期生命決定因子を調査する.
主な方法:
- 予見的なコホート研究では,発症時の心血管疾患およびAFのない45歳以上の女性27,982人を追跡しました.
- 出生体重は分類され,インシデントAFは平均14.5年以上にわたって追跡されました.
- 多変量コックス回帰モデルを使用して,様々な要因を調整して,出生体重カテゴリーにおけるAFの危険比率を評価しました.
主要な成果:
- 出生体重が高いカテゴリーは,インシデントAFのリスクが有意に増加した (線形動向P=0.002) と関連していました.
- この関連性は,BMI,血圧,糖尿病を調整した後も持続した.
- モデルに身長と若い成人の体重を含めると,観察された関係が弱まった.
結論:
- 出産時の体重は,女性における心房細動の有意な予測因子である.
- これらの発見は,AFの長期的な発達において,生命の初期に起因する要因の潜在的な役割を強調しています.
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