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Updated: Jun 9, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

エナチオセレクティブモノヒドロゲネーションによるメソサイクルイミドの脱対称化

Satoshi Takebayashi1, Jeremy M John, Steven H Bergens

  • 1Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2.

Journal of the American Chemical Society
|August 26, 2010
PubMed
まとめ

チラルのサイクルイミドは,不対称な水素化を経て,ルテニウム触媒を用いて高エナチオ選択性を持つヒドロキシラクタムを生成する. この脱対称化反応は,複数のステレオセンターを効率的に生成し,複雑な分子合成を可能にします.

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