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Updated: Jun 9, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
08:43

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Published on: January 19, 2016

N-ノシロキシカルバメートによるアニリドのPd触媒化された分子間オーソ-C-Hアミデーション

Ka-Ho Ng1, Albert S C Chan, Wing-Yiu Yu

  • 1State Key Laboratory for Chirosciences and The Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

Journal of the American Chemical Society
|August 26, 2010
PubMed
まとめ

新しいパラジアム触媒反応により,N-ノシロキシカルバメトを用いたアニリドから2アミノアニリンを合成することができる. この方法は,温和な条件,高い選択性,および有機合成のための幅広い機能群耐性を提供します.

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ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH301:11

ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
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Preparation of Carboxylic Acids: Hydrolysis of Nitriles

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Preparation of Amines: Reduction of Oximes and Nitro Compounds

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Though catalytic hydrogenation can reduce nitrobenzenes, the reduction is nonselective in the presence of other functional groups. For instance, if nitrobenzene contains an aldehyde group,...
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Amides are synthesized by treating carboxylic acids with amines in the presence of dehydrating agents like dicyclohexylcarbodiimide (DCC).
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Nitriles to Carboxylic Acids: Hydrolysis

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