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Updated: Jun 9, 2026

Measuring RAN Peptide Toxicity in C. elegans
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アタキシン-2 中間の長さのポリグルタミン拡張は,ALSのリスクの増加と関連しています

Andrew C Elden1, Hyung-Jun Kim, Michael P Hart

  • 1Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Nature
|August 27, 2010
PubMed
まとめ

アタキシン2 (ATXN2) 中間ポリグルタミン増幅は,アミオトロフィック横筋硬化症 (ALS) と関連しています. この発見は,ALSおよび関連する神経変性疾患の潜在的な治療標的として,ATXN2-TDP-43の相互作用を強調しています.

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Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells

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