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Updated: May 10, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

小型のウイルスタンパク質によるp53標的遺伝子のヘテロクロマチンの静止は,小さなウイルスタンパク質によるp53標的遺伝子の静止です

Conrado Soria1, Fanny E Estermann, Kristen C Espantman

  • 1Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, California 92037-1099, USA.

Nature
|August 27, 2010
PubMed
まとめ

アデノウイルスタンパク質E4-ORF3は,表遺伝的メカニズムを通じて,腫瘍抑制剤p53 (TP53とも呼ばれる) を静止させます. この新しい経路は,p53の安定化とは関係なく,p53がDNAに結合するのをブロックする核構造の形成を伴う.

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