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IkappaBbetaは,炎症反応中に遺伝子発現を抑制し,活性化するように作用します

Ping Rao1, Mathew S Hayden, Meixiao Long

  • 1Department of Immunobiology and Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Nature
|August 27, 2010
PubMed
まとめ

カッパBベータの阻害剤 (IkappaBbeta) は,炎症において二重の役割を果たしています. その分解は炎症性遺伝子発現を促進しますが,その核形態は腫瘍死滅因子アルファ (TNF-alpha) の生成を延長し,治療標的を提供します.

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