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Updated: Jun 9, 2026

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
09:16

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

アルファ-シヌクレインは,SNARE複合体の組み立てを vivo および in vitro で促進する

Jacqueline Burré1, Manu Sharma, Theodoros Tsetsenis

  • 1Department of Molecular and Cellular Physiology, and Howard Hughes Medical Institute, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304-5543, USA.

Science (New York, N.Y.)
|August 28, 2010
PubMed
まとめ

アルファ-シヌクレインを含むシヌクレインは,神経末端の溶性N-エチルマレイミド感受因子結合タンパク質受容体 (SNARE) 複合体の組み立てを維持するためにチャペロンとして作用します. シヌクレインの喪失は,老化による神経学的衰退とマウスの早死につながる.

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Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays

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Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons10:03

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons

Published on: August 16, 2020

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