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Updated: Jun 9, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

ヴィンドロシン,ヴィンドロリン,および主要なヴィンブラスティン類の非対称的全合成

Yoshikazu Sasaki1, Daisuke Kato, Dale L Boger

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|September 3, 2010
PubMed
まとめ

ヴィンドロリンとヴィンドロシンの簡潔な合成は,新しいサイクロアディションカスケードを使用して達成されました. この方法は,重要なステレオセンターと構造的特徴を効率的に確立し,生物学的研究のための新しいアナログの作成を可能にしました.

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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine11:04

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