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Updated: Jun 9, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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循環型Py-Imポリアミドアロステリック抑制による核受容体結合の構造的基礎

David M Chenoweth1, Peter B Dervan

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

Journal of the American Chemical Society
|September 4, 2010
PubMed
まとめ

ピロールイミダゾールポリアミドは,DNAを結合し,遺伝子発現を変更するプログラム可能な分子です. 新しい結晶構造は,これらのサイクルポリアミドが,DNAの形を変えることで,転写因子の結合を乱す方法を示しています.

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