アンチフォスフォリピドシンドローム
Guillermo Ruiz-Irastorza1, Mark Crowther, Ware Branch
1Service of Internal Medicine, Hospital de Cruces-University of the Basque Country, Bizkaia, Spain. r.irastorza@euskalnet.net
Lancet (London, England)
|September 9, 2010
まとめ
アンチフォスフォリピド症候群 (APS) は,血栓形成と妊娠合併症を伴う. 効果的な管理には,抗凝固薬,アスピリン,ヘパリンが含まれ,スタチンやリトゥキシマブなどの新しい治療法に関する研究が継続されています.
科学分野:
- 免疫学 免疫学とは
- 血液学 ヘマトロジ
- 産科は産婦人科です.
背景:
- アンチフォスフォリピド症候群 (APS) は,血栓形成と妊娠病変によって特徴付けられます.
- 臨床的特徴には,静脈,動脈,小血管の血栓症,妊娠中絶,子宮前出血症が含まれています.
- 病原発生には,アンチフォスフォリピド抗体が内皮細胞,血小板,単細胞を活性化し,補完体の活性化を潜在的に含む.
研究 の 目的:
- 抗リンパ脂症候群の臨床的表れ,病原性,および管理をレビューする.
- APSの特徴を予測するルプス抗凝固剤の役割を強調する.
- APSの現在のおよび潜在的な将来の治療法について議論する.
主な方法:
- アンチフォスフォリピド症候群の文献レビュー.
- 抗体と補完体を含む病原性機構の分析.
- 血栓形成および産科合併症に対する治療戦略の評価.
主要な成果:
- ルプス抗凝固剤は,APSの特徴の最も強い予測因子です.
- 長期の経口抗凝固薬は,血栓形成症治療の礎石である.
- アスピリンとヘパリンは,産科のAPS管理に推奨されます.
結論:
- APSは,特定の患者グループにおいて,動脈事件と血栓予防療法に対する積極的な治療を必要とします.
- 妊婦の患者にとって,医療産婦人科の併用管理は極めて重要です.
- 将来の治療法は,スタチン,リトゥキシマブ,新しい抗凝固剤を含む可能性があります.
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