コロニー形成ユニットと冠動脈と腹部大動脈の結石化との関連
Susan Cheng1, Kenneth S Cohen, Stanley Y Shaw
1Cardiology Division, GRB-800, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Circulation
|September 9, 2010
まとめ
血管修復に不可欠な内皮原生細胞の数が少なくなることは,動脈における動脈硬化症の増加と関連しています. これは,血管新生の可能性の低下が疾患発症を促す可能性があることを示唆しています.
科学分野:
- 心血管科学の研究について
- 細胞生物学 細胞生物学
- 医学科学 医学科学 医学科学 医学科学
背景:
- 内皮原始細胞 (EPC) は血管新生活性を持っています.
- EPCの枯渇は,アテロゲネシスを促進する可能性があります.
- 限られたヒトデータでは,EPCと亜臨床性動脈硬化症の関連が示されています.
研究 の 目的:
- EPCとヒトにおける亜臨床性動脈硬化症の関連性を調査する.
- EPC値が冠動脈結晶化および腹部大動脈結晶化と相関するかどうかを判断する.
主な方法:
- 臨床的な心血管疾患のないフレミングハム心臓研究 (Framingham Heart Study) の889人の参加者を研究した.
- 早期発芽コロニー形成ユニット (CFU) アッセイと細胞表面マーカーを用いてEPCを評価した.
- 計算機トモグラフィを用いた冠動脈結晶化および腹部大動脈結晶化による量化亜臨床性動脈硬化.
主要な成果:
- 下部EPCコロニー形成ユニットは,上部冠動脈と腹部大動脈の化と相関しています.
- CFUの1 - SD増加は,リスク要因とは無関係に,カルシフィケーションの ~16-17% の減少と関連していました.
- 特定のマーカー (CD34+/KDR+,CD34+) は,カルシフィケーションと有意な関連性を示さなかった.
結論:
- 減少したEPC数は,冠動脈と大動脈における亜臨床性動脈硬化症の負荷の増加と関連しています.
- 血管新生の可能性の低下は,ヒト集団における動脈硬化症の発症に寄与する可能性があります.
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