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Updated: Jun 8, 2026

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
06:44

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging

Published on: April 28, 2021

RETRACTED:ヒトSIRT6は,CtIP脱エチル化によるDNA末端解切を促進する

Abderrahmane Kaidi1, Brian T Weinert, Chunaram Choudhary

  • 1Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

Science (New York, N.Y.)
|September 11, 2010
PubMed
まとめ

シルトゥイン6 (SIRT6) タンパク質は,二重鎖破裂 (DSB) 修復の際にDNA末端解剖を支援することにより,DNA修復を促進します. SIRT6によるCtIP (C末端結合タンパク質相互作用タンパク質) の脱エチル化は,このプロセスの鍵であり,ゲノムの安定性を高めます.

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Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique09:14

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