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Updated: Jun 2, 2026

Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples
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USP14の小分子阻害剤によるプロテアソーム活性増強

Byung-Hoon Lee1, Min Jae Lee, Soyeon Park

  • 1Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

Nature
|September 11, 2010
PubMed
まとめ

USP14はプロテアソーム関連酵素で,タンパク質の分解を抑制する. USP14を阻害すると,プロテアソームの活性が向上し,神経変性疾患に関与する有毒なタンパク質のクリアランスを促進し,酸化ストレスに対する細胞抵抗性を改善します.

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