EphBシグナリングは,SOX2依存シュワンの細胞分類を通じて,外周神経再生を誘導する
Simona Parrinello1, Ilaria Napoli, Sara Ribeiro
1MRC Laboratory for Molecular Cell Biology and the UCL Cancer Institute, University College London, Gower Street, London WC1E 6BT, UK.
Cell
|September 28, 2010
まとめ
繊維芽細胞とシュワン細胞は,エフリン-B/EphB2シグナル伝達を通じて神経修復を調整する. これは,再生する軸索を誘導し,組織再生と幹性因子Sox2の関与のための新しいメカニズムを明らかにします.
科学分野:
- 神経科学は神経科学である.
- 細胞生物学 細胞生物学
- 再生医学は,再生医療である.
背景:
- 周回神経の損傷は,重要な再生反応を誘発する.
- シュヴァン細胞は,軸索の再生を支えるために,原始細胞へと分化します.
- 神経再生における線維芽細胞のような非ニューロン細胞の役割は,ますます認識されています.
研究 の 目的:
- 外周神経再生における線維芽細胞とそのシュワン細胞とのシグナル伝達の役割を調査する.
- 神経損傷後のシュワンの細胞移動と軸索誘導の基礎となる分子メカニズムを解明する.
主な方法:
- 外周神経損傷のin vivoモデルを利用した.
- 繊維芽細胞とシュワン細胞間のエフリンB/EphB2信号伝達経路を調査した.
- 細胞間の相互作用における幹性因子Sox2とN-カデリンの役割を調査した.
主要な成果:
- エフリンB/エフB2信号は,線維芽細胞とシュワン細胞の間の細胞分類と方向性シュワン細胞移動を媒介する.
- Sox2とN-カデリンは,EphB2媒介の細胞分類とシュワンン細胞組織に不可欠です.
- EphB2シグナル伝達の障害は,Schwann細胞の移動が損なわれ,in vivoでは軸索の再生が誤って方向づけられる.
結論:
- 繊維芽細胞は,シュヴァン細胞と信号を送り,神経再生に積極的に参加する.
- エフリン-B/エフB2シグナル伝達は,Sox2と組み合わせて,シュヴァン細胞の移住をオーケストラ化し,再生する軸索を誘導するメカニズムを提供します.
- この研究は,神経修復中の組織形成と環境のシグナルを結びつける新しい経路を発見しました.
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