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Updated: Jun 8, 2026

Sequential Salt Extractions for the Analysis of Bulk Chromatin Binding Properties of Chromatin Modifying Complexes
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Sequential Salt Extractions for the Analysis of Bulk Chromatin Binding Properties of Chromatin Modifying Complexes

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BETブロモドメインの選択的阻害

Panagis Filippakopoulos1, Jun Qi, Sarah Picaud

  • 1Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.

Nature
|September 28, 2010
PubMed
まとめ

研究者たちは,ブロモドメインと呼ばれるエピジェネティックリーダータンパク質を阻害する小さな分子であるJQ1を開発しました. この分子は,BRD4タンパク質を標的とし,新しい治療戦略を提供することで,特定のがんの治療に希望を示しています.

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