双子の双子の輸血症候群における異常なミトラルアーケード
Elizabeth Losada1, Anita J Moon-Grady, William C Strohsnitter
1Department of Pathology, University of California, San Francisco, 513 Parnassus Ave, Box 0511, San Francisco, CA 94143-0511, USA.
Circulation
|September 30, 2010
まとめ
異常なミトラルアーケード,珍しい心弁の欠陥は,双子双子の輸血症候群の受容胎児の36%で発見されました. 左心房の膨張やミトラル再発などのエコーカルディオグラフィの発見は,この既得症状を示唆する可能性があります.
科学分野:
- 心臓病学 心臓病学
- 胎児医学 胎児医学について
- 病理学 パトロジー
背景:
- 双子同胞輸血症候群 (TTTS) は,受容生胎児に心不全を引き起こす可能性があります.
- 異常なミトラルアーケード,ミトラル弁の希少な変形は,TTTSの解剖症例で特定されています.
- この状態は,ミトラル反発症と関連しています.
研究 の 目的:
- TTTS受容者における異常なミトラルアーケードの臨床病理学的プロフィールを定義する.
- 影響を受けたと影響を受けていないTTTS双子のペアを比較する.
- 異常なミトラルアーケードを示唆するエコーカルディオグラフィのマーカーを特定するために.
主な方法:
- 11人の検死 TTTS 双子のペアの臨床病理学的データの比較分析.
- ミトラル弁の構造の詳細な検査,小葉の形状と帯を含む.
- 心臓の機能,腔室の寸法,弁動力のエコーカルディオグラフィの評価.
主要な成果:
- 異常なミトラルアーケードは,TTTSを受けた11人の胎児のうち4人の胎児 (36%) で特定されました.
- 罹患した受容者は,厚い繊維帯状の束縛状の小冊子と欠席した/短い帯を披露していた.
- 受信者の心臓はより大きく,すべて中等から重度の心機能不全,左心房拡大,ミトラル再発症を示した.
結論:
- アノマル・ミトラル・アーケードは,これまで報告されていないTTTSの発見であり,このシリーズの受容者の36%で発生しています.
- 左心房の膨張,ミトラル反吐,および小葉の移動性の低下に関するエコーカルディオグラフィの発見は,異常なミトラルアーケードを示唆しています.
- TTTS受容者における異常なミトラルアーケードの発生は,この文脈で得られた弁の変形である可能性を示唆しています.
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