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強力なバクテリアのRNAポリメラーゼ阻害剤であるストレプトリジジンの合成

Sergey V Pronin1, Sergey A Kozmin

  • 1University of Chicago, Department of Chemistry, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.

Journal of the American Chemical Society
|October 1, 2010
PubMed
まとめ

科学者たちは,強力な抗生物質であるストレプトリジジンの最初の合成を達成しました. バクテリアのRNAポリメラーゼを阻害するこの複雑な分子は,収束し,ステレオ制御された24段階のプロセスを用いて構築されました.

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