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Updated: May 2, 2026

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オステオクラストの分化因子RANKLは,プロゲスティン誘発性乳がんの発生を制御する

Daniel Schramek1, Andreas Leibbrandt, Verena Sigl

  • 1IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria.

Nature
|October 1, 2010
PubMed
まとめ

MPAのような合成プロゲスティンは,乳がん細胞にRANKLを誘発することによって,乳がんリスクを高めます. 乳腺上皮細胞のRANKL/RANK経路を阻害することで,がんの発症を予防し,プロゲステン誘発性乳がんの重要なメカニズムを明らかにする.

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