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Updated: Jun 8, 2026

Immunolabelling Myofiber Degeneration in Muscle Biopsies
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Immunolabelling Myofiber Degeneration in Muscle Biopsies

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ミオゲニンとクラスIIのHDACは,E3ユビキチンリガゼを誘導することにより,神経原性筋肉縮を制御する

Viviana Moresi1, Andrew H Williams, Eric Meadows

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|October 5, 2010
PubMed
まとめ

筋肉の発達調節体であるミオゲニンは,筋肉を損なうタンパク質を上調することで,神経原性縮を誘発します. ミオゲニンまたは特定のヒストン脱酸化酵素 (HDACs) を阻害すると,デナーベーション後の筋肉損失から保護できます.

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