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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

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Updated: Jun 8, 2026

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells
06:02

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells

Published on: October 28, 2025

人間の細胞における強化剤のような機能を持つ長いノンコーディングRNA.

Ulf Andersson Ørom1, Thomas Derrien, Malte Beringer

  • 1The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

Cell
|October 5, 2010
PubMed
まとめ
この要約は機械生成です。

長いノンコーディングRNA (ncRNA) は驚くほど遺伝子発現を活性化し,その機能に関する以前の理解に挑戦しています. この研究は,重要な発達遺伝子の調節におけるそれらの役割を明らかにしています.

さらに関連する動画

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells
03:34

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells

Published on: November 21, 2025

関連する実験動画

Last Updated: Jun 8, 2026

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells
06:02

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells

Published on: October 28, 2025

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells
03:34

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells

Published on: November 21, 2025

科学分野:

  • ゲノミクスゲノミクスとは
  • 分子生物学は分子生物学である.
  • エピジェネティクス エピジェネティクス

背景:

  • 長いノンコーディングRNA (ncRNA) は哺乳類のトランスクリプトームの重要な部分を占めるが,その機能はほとんど不明である.
  • 現存する研究では,ncRNAsを主にX不活性化やインプリントングのような遺伝子サイレンスメカニズムと関連付けている.

研究 の 目的:

  • GENCODEヒトゲノムアノテーションを使用して長いncRNAを特徴付ける.
  • 遺伝子発現の調節における長いncRNAの機能的役割を調査する.

主な方法:

  • GENCODEアノテーションを使用して,複数のヒト細胞系で発現する千以上の長いncRNAを識別しました.
  • 隣接するタンパク質をコードする遺伝子発現への影響を評価するために,遺伝子枯渇実験を行った.
  • 遺伝子の活性化におけるncRNAsの役割を確認するために,異質の転写アッセイを使用した.

主要な成果:

  • 人間の細胞系における長いncRNAsのサブセットに対する予期せぬ強化剤のような機能を特定した.
  • 特定のncRNAsの枯渇は,SCL (TAL1),Snai1およびSnai2.2のような重要な発達レギュレータを含む,近くのタンパク質をコードする遺伝子の発現を低下させた.
  • 遺伝子発現を活性化するためにこれらのncRNAの必要性を実証した.

結論:

  • 遺伝子発現の活性化剤としての長いノンコーディングRNAの新たな役割を明らかにした.
  • 開発と分化に不可欠な重要な遺伝子を調節する ncRNAs の関与を強調します.
  • ncRNAsを遺伝子サイレンサーとしてのみ見るという支配的な見解に異議を唱える.