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Updated: Jun 8, 2026

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer
07:13

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Published on: March 26, 2014

乳がん腫瘍におけるSPCA2によるOrai1のストア独立活性化

Mingye Feng1, Desma M Grice, Helen M Faddy

  • 1Department of Physiology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.

Cell
|October 5, 2010
PubMed
まとめ

分泌経路Ca2+) -ATPase 2 (SPCA2) のアップレギュレーションは,Orai1.1経由でカルシウム流入を増やすことで乳がんを促進する. SPCA2を抑制すると,カルシウムレベルと腫瘍の成長が低下し,新たな腫瘍発生経路が明らかになる.

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