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Updated: Jun 8, 2026

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase
11:57

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase

Published on: June 24, 2025

ファミリアル・アクネ・インバーサにおけるガンマ分泌酵素遺伝子変異

Baoxi Wang1, Wei Yang, Wen Wen

  • 1Peking Union Medical College Hospital, Chinese Academy of Medical Sciences-Peking Union Medical College (CAMS-PUMC), Beijing, China.

Science (New York, N.Y.)
|October 9, 2010
PubMed
まとめ

ファミリアル・アクネ・インバーサ (AI) は, γ-セクレターゼ複合体の遺伝子の変異と関連しています. この発見は,AIの病原性におけるgα-secretase-Notch経路を暗示し,それをアルツハイマー病と結びつける.

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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms06:40

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

Published on: January 25, 2018

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