RORガマト+先天性リンパ性細胞の系統関係分析
Shinichiro Sawa1, Marie Cherrier, Matthias Lochner
1Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France.
まとめ
プロ炎症性RORγt (((+) 生まれながらのリンパ性細胞 (ILCs) はリンパ性組織の発達と腸内ホメオスタシスを開始します. これらの細胞は微生物群から独立して発達し,微生物のコロニー化を防ぐ役割があることを示唆しています.
科学分野:
- 免疫学 免疫学とは
- 発達生物学 発達生物学とは
- マイクロバイオーム研究
背景:
- リンパ性組織誘発細胞 (LTi) は,ストロマ細胞の活性化によってリンパ性組織の発達を開始します.
- LTi細胞は,核ホルモン受容体RORγtを発現し,これはT細胞のインタールイキン-17発現を調節する.
研究 の 目的:
- RORγtのより広いファミリーを特徴付けるために (((+) 生まれながらのリンパ性細胞 (ILCs).
- RORγt (((+) ILCsの発達経路と機能を腸内ホメオスタシスと微生物の相互作用に関連して調査する.
主な方法:
- 胎児および成人マウスのRORγt (((+) 細胞集団の分析.
- 胎児の肝臓前駆体からのILCの差別化を調査する.
- 微生物群の存在と欠如におけるILCの発達を評価する.
主要な成果:
- LTisは,胎児の肝臓前駆体から発生した,より大きなプロ炎症性RORγt (((+) ILCsのファミリーの一部です.
- RORγt (((+) ILCsの発達運命はマウスの年齢によって影響を受け,腸内ホメオスタシスと産後防御を好みます.
- RORγt (((+) ILCは,RORγt (((+) T細胞とは異なり,微生物群とは独立して発達する.
結論:
- RORγt ((+) ILCは,リンパ性組織形成の開始に関与する独特の先天性免疫細胞系統を表しています.
- これらの細胞は,腸内ホメオスタシスと防御メカニズムを確立する上で重要な役割を果たします.
- RORγt (((+) ILCsが微生物群なしで発達する能力は,微生物共生体によるコロニー化を先取りするためにプライムされていることを示唆しています.
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