Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview
Physiological Barriers01:25

Physiological Barriers

Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Factors Affecting Drug Distribution: Physiological Barriers01:23

Factors Affecting Drug Distribution: Physiological Barriers

Drug distribution in the body is intricately regulated by various physiological barriers that control the passage of substances. These include the capillary endothelial barrier, the blood-brain, blood-cerebrospinal fluid, blood-placental, and blood-testis barriers.
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
Cerebrospinal Fluid01:21

Cerebrospinal Fluid

Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Artery-Like Smooth Muscle Drives Contractile Function in Dural Venous Sinuses.

bioRxiv : the preprint server for biology·2026
Same author

GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Resolving thyroid lineage cell trajectories merging into a dual endocrine gland in mammals.

Nature communications·2026
Same author

Ki-67 promotes circulating tumor cell intravasation and metastasis in breast cancer.

Cell reports·2026
Same author

Efficient sampling of liver tissue for histological analysis of rodent MASLD/MASH models.

Histology and histopathology·2026
Same author

Therapeutic efficacy, biomarker signatures, and translatability of semaglutide in the liver biopsy-confirmed GAN DIO-MASH mouse model.

American journal of physiology. Gastrointestinal and liver physiology·2026

関連する実験動画

Updated: Jun 8, 2026

A High Output Method to Isolate Cerebral Pericytes from Mouse
06:49

A High Output Method to Isolate Cerebral Pericytes from Mouse

Published on: January 14, 2020

ペリサイトは,血脳障壁を調節する.

Annika Armulik1, Guillem Genové, Maarja Mäe

  • 1Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden. annika.armulik@ki.se

Nature
|October 15, 2010
PubMed
まとめ

ペリサイトは,血脳障壁 (BBB) の完全性を維持する上で重要な役割を果たします. 欠乏すると,BBBの透過性が増加し,中枢神経系 (CNS) 経由する水とトレーサーに影響を及ぼします.

さらに関連する動画

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease
06:19

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease

Published on: October 20, 2023

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue
06:35

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue

Published on: September 12, 2018

関連する実験動画

Last Updated: Jun 8, 2026

A High Output Method to Isolate Cerebral Pericytes from Mouse
06:49

A High Output Method to Isolate Cerebral Pericytes from Mouse

Published on: January 14, 2020

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease
06:19

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease

Published on: October 20, 2023

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue
06:35

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue

Published on: September 12, 2018

科学分野:

  • 神経科学は神経科学である.
  • 細胞生物学 細胞生物学
  • 生理学 生理学とは

背景:

  • 血脳障壁 (BBB) は,物理的障壁,酵素,トランスポーターを通じて中枢神経系 (CNS) を保護する.
  • 内皮の緊密な結合が鍵となる一方で,BBB機能におけるアストロサイトとペリサイトの役割は完全に理解されていません.

研究 の 目的:

  • 血脳障壁の浸透性と機能を調節するペリサイトのインビボの役割を調査する.
  • ペリサイトがBBBの性質に影響を与えるメカニズムを解明する.

主な方法:

  • 成人生存可能なペリサイト欠乏マウス変異体を使用した.
  • 水と様々な分子量トレーサーに対するBBBの浸透性を評価した.
  • BBBの透過性に対するイマチニブの効果を調査した.
  • 腸内細胞の遺伝子発現とアストロシトの極化に関するペリサイト媒介による調節を分析した.

主要な成果:

  • ペリサイト欠乏症は,BBBの水とトレーサーへの浸透性を著しく増加させた.
  • 浸透性の向上は,イマチニブで可逆性の強化された内皮トランサイトーシスに起因した.
  • ペリサイトは,BBB特異的な内皮基因発現を調節し,アストロサイト末足の極化を引き起こします.

結論:

  • ペリサイトは,血液脳壁の整合性を維持するために不可欠です.
  • ペリサイトは,神経血管単位で内皮細胞とアストロサイト機能を統合する.
  • ペリサイトは,中枢神経系の障壁機能を調節する上で,新しい重要な役割を果たします.