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Updated: Jun 7, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

循環的論理:非リボソームペプチド型のマクロサイクライゼーションでリボソームペプチド触媒を用いる

John A McIntosh1, Charles R Robertson, Vinayak Agarwal

  • 1Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.

Journal of the American Chemical Society
|October 22, 2010
PubMed
まとめ

リボソームペプチド生物合成で発見された新しいプロテアゼは,非リボソームペプチド製品に類似した様々な分子をマクロサイクルすることができます. この酵素はアミド結合を利用し,その基質化学においてチオエステラーゼ機構と異なる.

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