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Updated: Jun 7, 2026

Combined DNA-RNA Fluorescent In situ Hybridization (FISH) to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
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母のRnf12/RLIMは,マウスのインプリントされたX染色体不活性化のために必要である

Jongdae Shin1, Michael Bossenz, Young Chung

  • 1Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS), Worcester, Massachusetts 01605, USA.

Nature
|October 22, 2010
PubMed
まとめ

母親のRnf12/RLIMは,雌マウスの胚でインプリントされたX染色体不活性化 (XCI) を開始するために不可欠です. その欠如は,Xist RNAの雲形成と,父親のX染色体の沈黙を妨害し,胚の致死性につながる.

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