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Updated: Jun 7, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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リンガゼPIAS1は,表遺伝的抑圧によって,自然に調節されるT細胞の分化を制限する

Bin Liu1, Samuel Tahk, Kathleen M Yee

  • 1Division of Hematology-Oncology, Department of Medicine, 11-934 Factor Building, 10833 Le Conte Avenue, University of California, Los Angeles, Los Angeles, CA 90095, USA. bliu@ucla.edu

Science (New York, N.Y.)
|October 23, 2010
PubMed
まとめ

SUMO E3リガゼPIAS1は,Foxp3プロモーターをエピジェネティックに静止させることで,規制性T細胞の分化を制限する. Pias1の消去は,調節性T細胞集団と自己免疫疾患に対する耐性を高めます.

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