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Updated: Jun 7, 2026

Affinity Precipitation of Active Rho-GEFs Using a GST-tagged Mutant Rho Protein (GST-RhoA(G17A)) from Epithelial Cell Lysates
11:28

Affinity Precipitation of Active Rho-GEFs Using a GST-tagged Mutant Rho Protein (GST-RhoA(G17A)) from Epithelial Cell Lysates

Published on: March 31, 2012

RhoA GEF Ephexin5のEphB媒介による分解は,刺激性シナプス形成の発達ブレーキを緩和する

Seth S Margolis1, John Salogiannis, David M Lipton

  • 1Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|October 30, 2010
PubMed
まとめ

研究者らは,エフェキシン5が刺激シナプスの発達を制限することを発見した. エフリンB/エフBのシグナル伝達によって誘発され,Ube3Aによって媒介されるその分解は,シナプス形成を促進し,エンジェルマン症候群や自閉症スペクトル障害などの認知障害に潜在的に影響を及ぼします.

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